Abstract #4504

Simultaneous Extraction of ADC and T2: Validation of Quantified DESS Sequence at 3T and 7T

Forrest Howell¹, Haonan Wang¹, Daniel Park², Meredith Taylor¹, Bragi Sveinsson³, and Neal Bangerter¹

¹Electrical Engineering, Brigham Young University, Provo, UT, United States, ²Biomedical Imaging, Electrical Engineering, University of Oxford, Oxford, United Kingdom, ³Radioligy, Stanford University, Palo Alto, CA, United States

A modification of the dual-echo steady state (DESS) pulse sequence was recently proposed that allows the extraction of both T2 and apparent diffusion coefficient (ADC) maps from a pair of DESS acquisitions (termed quantitative DESS, or qDESS). A careful validation of the accuracy of the qDESS T2 and ADC estimates has not yet been performed. The qDESS sequence produces accurate, high-resolution ADC and T2 maps. This is especially notable at 7T, where transmit B1 inhomogeneity makes it very difficult to produce reasonable T2 maps using typical multi-echo spin echo techniques. The qDESS technique shows great promise in providing both high-resolution morphological data and maps of T2 and ADC at 3 and 7 Tesla.

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