Abstract #4506

Loading Significantly Influences the Zonal T1 of Medial Tibial Cartilage Topographically

Ji Hyun Lee^1,2, Farid Badar^1,2, John Matyas³, and Yang Xia^1,2

¹Physics, Oakland University, Rochester, MI, United States, ²Center for Biomedial Research, Oakland University, Rochester, MI, United States, ³Univeristy of Calgary, Calgary, AB, Canada

This study aims to quantify the loading-modified T1 in articular cartilage using a canine model of early osteoarthritis (OA) at different degradation stages, at a 17.6µm resolution and with the use of Gd contrast agent. Both lesion and mechanical compression were found to alter T1 in cartilage at each sub-tissue zone and topographically, which provide a better understanding of the MRI properties of cartilage during joint loading. This result could help to design effective protocols in clinical MRI to better detect and manage the osteoarthritic diseases.

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