Abstract #4526

Fat infiltration is non-uniform along the proximodistal muscle axis in Duchenne Muscular Dystrophy

Melissa Hooijmans¹, Nathalie Doorenweerd¹, Jedrek Burakiewicz¹, Jan Verschuuren², Constantin Anastasopoulos¹, Andrew Webb¹, Erik Niks², and Hermien Kan¹

¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Neurology, Leiden University Medical Center, Leiden, Netherlands

Progressive replacement of muscle tissue by fat is one of the main characteristics of DMD. This muscle degeneration process has been extensively studied in terms of differences between individual muscles, but not as a function of physical location within each individual muscle. This work showed non-uniform fat infiltration along the proximodistal muscle axis within individual muscles using the Dixon water/fat technique. These observations provide new insight into disease progression in DMD.

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