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Abstract #0005

A Combined 7 Tesla MRI/NMR Probe Head for Photochemical Applications.

Jens Groebner1, Gernot Heitmann1, Marcel Dommaschk1, Lukas M. Huber2, Eduard Stadler3, Reiner Umathum4, Frank D. Sönnichsen1, and Rainer Herges1

1Otto Diels Institute for Organic Chemistry, Kiel University, Kiel, Germany, 2Molecular Imaging North Competence Center, University Medical Center Schleswig-Holstein, Kiel, Germany, 3Institute of Physical and Theoretical Chemistry, Graz University of Technology, Graz, Austria, 4Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany

The development of new photoswitchable contrast agents requires analysis with both NMR and MRI. In this work a combined probe head for in situ light exposure is presented which can be used on NMR and MRI systems with both 7 Tesla. A probe head with four slanted quartz rods was fabricated. A dual tuned (1H and 2H) Helmholtz coil was integrated into the probe head. NMR and MRI experiments were performed on photoswitchable solutions (e.g. contrast agents). Results show that photoswitchable solutions can be successfully switched in situ and simultaneously analyzed with NMR or imaged with MRI.

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