Abstract #0005

A Combined 7 Tesla MRI/NMR Probe Head for Photochemical Applications.

Jens Groebner¹, Gernot Heitmann¹, Marcel Dommaschk¹, Lukas M. Huber², Eduard Stadler³, Reiner Umathum⁴, Frank D. Sönnichsen¹, and Rainer Herges¹

¹Otto Diels Institute for Organic Chemistry, Kiel University, Kiel, Germany, ²Molecular Imaging North Competence Center, University Medical Center Schleswig-Holstein, Kiel, Germany, ³Institute of Physical and Theoretical Chemistry, Graz University of Technology, Graz, Austria, ⁴Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany

The development of new photoswitchable contrast agents requires analysis with both NMR and MRI. In this work a combined probe head for in situ light exposure is presented which can be used on NMR and MRI systems with both 7 Tesla. A probe head with four slanted quartz rods was fabricated. A dual tuned (¹H and ²H) Helmholtz coil was integrated into the probe head. NMR and MRI experiments were performed on photoswitchable solutions (e.g. contrast agents). Results show that photoswitchable solutions can be successfully switched in situ and simultaneously analyzed with NMR or imaged with MRI.

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