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Abstract #0013

Interventional Magnetic Resonance Imaging Guided Carotid Embolectomy using a Novel MRI-Conditional Resonant Catheter: Demonstration of Preclinical Feasibility

Jeffrey K. Yang1, Andre Cote1, Caroline D. Jordan1, Aaron Losey1, David McCoy1, Andrew Chu2, Jay F. Yu1, Teri Moore1, Carol Stillson1, Fabio Settecase1, Matthew D. Alexander1, Andrew Nicholson1, Mariam Aboian1, Daniel L. Cooke1, Maythem Saeed1, Dave Barry2, Alastair J. Martin1, Mark W. Wilson1, and Steven W. Hetts1

1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Penumbra Inc, Alameda, CA, United States

MR-guided endovascular interventions can provide real-time imaging biomarkers for procedures such as stroke embolectomy. The purpose of this study is to determine preclinical feasibility and efficacy of imaging wireless resonant circuits embedded in a MR compatible catheter system for in vivo MR-guided carotid embolectomy in porcine stroke models. The resonant catheter system performed effectively under real-time MRI with recanalization rates (TICI 2b/3) similar to reported clinical rates in stroke embolectomy. Qualitative physiologic measures of flow under MRI were comparable to those measured under X-ray, demonstrating feasibility of resonant catheter system for in vivo carotid occlusion and embolectomy under real-time MRI.

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