Abstract #0021

3D magnetic resonance spectroscopic imaging at 7 Tesla of patients with medically refractory focal epilepsy with non-lesional or inconclusive clinical MRIs: First Results

Rebecca Emily Feldman¹, Madeline Cara Fields², Bradley Neil Delman³, Lara Vanessa Marcuse⁴, and Priti Balchandani¹

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Neurology, Mount Sinai Hospital, New York, NY, United States, ³Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Neurology, Mount Sinai Hospital

SASSI is a B₁-insensitive, low-SAR 7T MRSI technique with reduced chemical shift localization errors. We used 3D SASSI to image the hippocampi of patients with medically refractory focal epilepsy who had non-lesional or inconclusive clinical MRIs. Using SASSI at 7T, we detected decreases in the hippocampal NAA/Cr ratios in suspected temporal lobe epilepsy patients, on the same side as the seizure onset zones and/or 7T structural findings.

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