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Abstract #0045

Myocardial extracellular volume expansion precedes functional myocardial alterations during the evolution of systemic sclerosis

Alexander Gotschy1,2, Constantin von Deuster1, Christian Stoeck1, Valeriy Vishnevskiy1, Lukas Wissmann1, Kerem Can Tezcan1, Markus Niemann3, Suzanna Jordan4, Britta Maurer4, Sebastian Kozerke1, Oliver Distler4, and Robert Manka2

1Institute for Biomedical Engineering, University & ETH Zurich, Zurich, Switzerland, 2Department of Cardiology, University Hospital Zurich, Zurich, Switzerland, 3Faculty Mechanical and Medical Engineering, Furtwangen University, Schwenningen, Germany, 4Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

Myocardial involvement is common in patients with systemic sclerosis and is known to cause myocardial fibrosis and subtle ventricular dysfunction. Both can be characterized by novel CMR methods like native T1-mapping, ECV quantification or LV deformation imaging. However, the temporal onset of myocardial fibrosis and functional impairment during the progression of the disease is still unknown. Therefore, we investigated the presence of subclinical functional and fibrotic myocardial involvement in patients with very early diagnosis of systemic sclerosis and found that the expansion of ECV can be detected before LV functional impairment, assessed by CMR feature tracking, can be observed.

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