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Abstract #0050

Acute white matter abnormalities in sport-related concussion: A DTI study

Sourajit Mitra Mustafi1,2, Jaroslaw Harezlak1,3, Kevin M Koch1,4, Andrew S Nencka1,4, Timothy B Meier1,4, Andrew J Saykin1,2, Micheal McCrea1,4, Thomas W McAllister1,5, and Yu-Chien Wu1,2

1Concussion Assessment, Research and Education (CARE) Consortium, Indianapolis, IN, United States, 2Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, United States, 3Department of Biostatistics, Indiana University, 4The Medical College of Wisconsin, 5Department of Psychiatry, Indiana University

In the present study, we use diffusion tensor imaging (DTI) to detect acute white matter alterations in football players after sport-related concussion. DTI scans were performed on 30 male football players who had acute concussion (24-48 hours post-injury). Another 28 matched contact-sport players were recruited as controls. Mean diffusivity (MD) increased significantly in concussive group compared to the contact-control group. Long fibers including corpus callosum, corona radiata, and longitudinal fasciculus were more vulnerable than the rest of the brain white matter. Within the concussed group, axial diffusivity (AD) demonstrated positive correlation with symptom severity indicating potential axonal changes/damage.

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