The purpose of this work was to study subjects with myotonic dystrophy (DM1) utilizing MRI to assess correlations between global cerebral white matter abnormalities, muscle structure, and muscle function. MRI-based measures of white matter (fractional anisotropy), muscle structure (volume, fat fraction, T2 mapping) along with muscle function testing demonstrated several significant correlations. The combination of neuroimaging and muscle structure assessment with MRI holds considerable promise towards elucidating the relationships between CNS abnormalities and neuromuscular dysfunction.
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