Abstract #0095

An MRI-based assessment of the correlation between cerebral white matter changes, muscle structure, and muscle function in myotonic dystrophy

Daniel Thedens¹, Cheryl Smith², Peg Nopoulos³, Richard Shields⁴, and Laurie Gutmann²

¹Radiology, University of Iowa, Iowa City, IA, United States, ²Neurology, University of Iowa, Iowa City, IA, United States, ³Psychiatry, University of Iowa, Iowa City, IA, United States, ⁴Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, United States

The purpose of this work was to study subjects with myotonic dystrophy (DM1) utilizing MRI to assess correlations between global cerebral white matter abnormalities, muscle structure, and muscle function. MRI-based measures of white matter (fractional anisotropy), muscle structure (volume, fat fraction, T2 mapping) along with muscle function testing demonstrated several significant correlations. The combination of neuroimaging and muscle structure assessment with MRI holds considerable promise towards elucidating the relationships between CNS abnormalities and neuromuscular dysfunction.

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