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Abstract #0104

Feasibility of glucose CEST in the human placenta

Jie Luo1, Yang Ji2,3, Esra Abaci Turk1, Iris Y Zhou2, Drucilla J. Roberts4, Patricia Ellen Grant1, and Phillip Zhe Sun2

1Fetal-neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, MA, United States, 3Center for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China, People's Republic of China, 4Pathology, Massachusetts General Hospital and Harvard Medical School, MA, United States

Placental glucose transfer is essential to sustain fetal development, yet there has been no report attempting to measure glucose transport across the human placenta with MRI-based approaches. Emerging glucose chemical exchange saturation transfer (glucoCEST) imaging is uniquely sensitive to glucose, which has been explored in tumor imaging. Herein, we have demonstrated glucoCEST MRI is a valid tool to monitor glucose perfusion in ex vivo human placenta, laying the groundwork for in vivo glucoCEST in human placenta.

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