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Abstract #0106

An exploration of quantitative physiological multi-modal in-vivo imaging of the human placenta

Jana Hutter1,2, Paddy J Slator3, Jonathan O'Muircheartaigh4, Rui P Azeredo Gomes Teixeira1, Anthony N Price1, Ana Dos Santos Gomes4, Laura McCabe4, Sophie Arulkumaran4, Mary Rutherford4, and Joseph V Hajnal1

1Biomedical Engineering Department, King's College London, London, United Kingdom, 2Centre for the Developing Brain, London, United Kingdom, 3Centre for Medical Image Computing, University College London, London, United Kingdom, 4Centre for the Developing Brain, King's College London, London, United Kingdom

The crucial role of the placenta in successful pregnancies is the transfer of oxygen within functional units – cotyledons. However, current screening falls short of visualizing this in-vivo. This study explores a multi-model in-vivo MRI acquisition able to visualize and depict a range of spatial and temporal processes and the underlying micro-structure. Diffusion characteristics such as Mean Diffusivity and fractional anisotropy, quantitative T2* maps, temporal characteristics and the depiction of vasculature allow insights and can be applied to a range of research questions.

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