Abstract #0106

An exploration of quantitative physiological multi-modal in-vivo imaging of the human placenta

Jana Hutter^1,2, Paddy J Slator³, Jonathan O'Muircheartaigh⁴, Rui P Azeredo Gomes Teixeira¹, Anthony N Price¹, Ana Dos Santos Gomes⁴, Laura McCabe⁴, Sophie Arulkumaran⁴, Mary Rutherford⁴, and Joseph V Hajnal¹

¹Biomedical Engineering Department, King's College London, London, United Kingdom, ²Centre for the Developing Brain, London, United Kingdom, ³Centre for Medical Image Computing, University College London, London, United Kingdom, ⁴Centre for the Developing Brain, King's College London, London, United Kingdom

The crucial role of the placenta in successful pregnancies is the transfer of oxygen within functional units – cotyledons. However, current screening falls short of visualizing this in-vivo. This study explores a multi-model in-vivo MRI acquisition able to visualize and depict a range of spatial and temporal processes and the underlying micro-structure. Diffusion characteristics such as Mean Diffusivity and fractional anisotropy, quantitative T2* maps, temporal characteristics and the depiction of vasculature allow insights and can be applied to a range of research questions.

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