An accelerated multi-shot diffusion imaging scheme was developed for prostate imaging. Its robustness to regularization was evaluated. Two-fold improvement in spatial resolution and over three-fold improvement in geometric fidelity were obtained as compared to single-shot EPI, in twenty-five prostate cancer patients. In contrast to the standard protocol, which involves separate scans with high (b=1400 and 0 s/mm2) and intermediate (b=500 and 0 s/mm2) diffusion weighting, the proposed accelerated protocol extended b-factor coverage to yield an additional 8 b-factors and enabled multi-b perfusion quantification in half the scan time (5 min 43 s vs. 11 min 48 s).
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