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Abstract #0112

Accelerated Segmented Diffusion-Weighted Prostate Imaging for Higher Resolution, Higher Geometric Fidelity, and Multi-b Perfusion Quantification

Pelin Aksit Ciris1, Jr-yuan George Chiou2, Daniel Glazer2, Shelley Hualei Zhang2, Tzu-Cheng Chao3, Bruno Madore2, and Stephan Ernst Maier2,4

1Department of Biomedical Engineering, Akdeniz University, Antalya, Turkey, 2Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, 3Department of Computer Science, National Cheng Kung University, Tainan City, Taiwan, 4University of Gothenburg, Gothenburg, Sweden

An accelerated multi-shot diffusion imaging scheme was developed for prostate imaging. Its robustness to regularization was evaluated. Two-fold improvement in spatial resolution and over three-fold improvement in geometric fidelity were obtained as compared to single-shot EPI, in twenty-five prostate cancer patients. In contrast to the standard protocol, which involves separate scans with high (b=1400 and 0 s/mm2) and intermediate (b=500 and 0 s/mm2) diffusion weighting, the proposed accelerated protocol extended b-factor coverage to yield an additional 8 b-factors and enabled multi-b perfusion quantification in half the scan time (5 min 43 s vs. 11 min 48 s).

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