Abstract #0126

Anatomical and functional deficits of the placenta identified by MRI in a rat model of preeclampsia

Emily Alexandria Waters¹, Pamela Monahan², Chad R Haney¹, Michael Kevin Fritsch³, Thomas J Meade⁴, and Kelly E Mayo²

¹Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL, United States, ²Molecular Biosciences, Northwestern University, Evanston, IL, United States, ³Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ⁴Chemistry, Molecular Biosciences, and Neurobiology, Northwestern University, Evanston, IL, United States

Though a large percentage of poor pregnancy outcomes such as stillbirth and preterm birth are related to placental dysfunction, the gold-standard of diagnosing placental pathology remains examination of the placenta by a pathologist after delivery. We demonstrate that anatomical and functional MRI can detect features of placental pathology correlating with ex vivo measures in a rat model of pre-eclampsia.

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