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Abstract #0154

Ultra-high resolution blood volume fMRI and BOLD fMRI in humans at 9.4 T: Capabilities and Challenges

Laurentius Huber 1, Desmond H Y Tse2, Kashyap Sriranga2, Christopher Wiggins3, Kâmil Uludağ2, Peter A Bandettini1, Benedikt A Poser2, and Dimo Ivanov2

1SFIM, NIMH, Bethesda, MD, United States, 2MBIC, Maastricht University, Netherlands, 3Scannexus, Maastricht, Netherlands

FMRI at ultra-high field strengths of 9.4 T allows functional imaging with submillimeter spatial resolutions. CBV sensitive VASO-fMRI has been suggested to be weighted towards locally specific microvasculature changes close to neural activity changes. Hence, we sought to combine the high physiological specificity of CBV-fMRI with the high signal-to-noise ratio of 9.4 T imaging. In our experiments, we could identify and discuss numerous technical challenges of CBV-fMRI at 9.4 T regarding constraints of RF fields and VASO contrast generation. With the application of advanced imaging methods, we show promising functional results with clearly visible cortical depth-dependent activity patterns.

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