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Abstract #0158

Frequency signature of cortical laminar fMRI

Maria Guidi1, Irati Markuerkiaga2, Lauren Bains2, Laurentius Huber3, Harald E. Möller1, and David G. Norris2

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Donders Centre for Cognitive Neuroimaging, Nijmegen, Netherlands, 3NIMH, Bethesda, MD, United States

The nature of spontaneous oscillations in the blood oxygenation level dependent (BOLD) response is in the focus of current research. For resting-state network studies, the low-frequency band (0.01-0.1 Hz) is usually taken to be relevant for neuronal activity. However, this statement is based on low-resolution functional data, where the effect of the draining vasculature cannot always be characterized. This study investigates the distribution of the amplitude of resting-state BOLD fluctuations using a sub-millimeter resolution and shows that the low-frequency band is dominating at all cortical depths, but most of its power is located at the pial surface.

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