Abstract #0193

Dynamic Glucose Enhanced Imaging at 3T: First Human Data

Xiang Xu^1,2, Akansha Sehgal^1,2, Nirbhay N. Yadav^1,2, Linda Knutsson^1,3, John Laterra⁴, Martin Pomper¹, Hailey Rosenthal¹, and Peter C.M. van Zijl^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Medical Radiation Physics, Lund University, Lund, Sweden, ⁴Department of Neurology, Johns Hopkins University, Baltimore, MD, United States

Recently, it has been demonstrated that D-glucose has potential as an MRI contrast agent at 7T for imaging dynamic changes upon glucose infusion in brain tumors using chemical exchange saturation transfer (CEST) MRI. Here we show first data for the possibility of translating such technique to 3T using pseudo-continuous wave saturation and extend the method to acquire a 3D volume (10 slices) for better brain coverage. We present dynamic glucose-enhanced (DGE) data from healthy volunteers and a brain tumor patient with a low grade glioma showing the feasibility of glucose enhanced imaging at clinical field strength.

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