Abstract #0204

Anisotropic cerebral vascular architecture causes orientation dependency in cerebral blood flow and volume measured with spin echo dynamic susceptibility contrast magnetic resonance imaging

Jonathan Doucette^1,2, Luxi Wei^1,3, Christian Kames^1,2, Enedino Hernández-Torres^1,4, Rasmus Aamand⁵, Torben E. Lund⁵, Brian Hansen⁵, and Alexander Rauscher^1,4

¹UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ²Engineering Physics, University of British Columbia, Vancouver, BC, Canada, ³Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁴Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁵Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

Cerebral white matter tissue perfusion measured with gradient echo dynamic susceptibility contrast (DSC) imaging exhibits a strong dependency on the angle between white matter fibres and the main magnetic field. Here, we investigate how spin echo DSC depends on the orientation of white matter and explain orientation effects by a model of diffusion within a magnetically inhomogenous environment created by a vascular bed with isotropic and anisotropic components. We found that the change in $$$R_2$$$ value for the SE DSC is 20% larger in WM fibres perpendicular to $$$B_0$$$ than for those parallel, compared with 100% larger in GRE DSC.

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