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Abstract #0212

Metabolic counterparts of sodium accumulation in Multiple Sclerosis: A whole brain 1H-MRSI and 23Na-MRI study

Maxime Donadieu1,2,3, Adil Maarouf1,4, Yann Le Fur1,4, Soraya Gherib1,4, Elisabeth Soulier1,4, Lauriane Pini1,4, Stanislas Rapacchi1,4, Sylviane Confort-Gouny1,4, Maxime Guye1,4, Jean Pelletier5, Bertrand Audoin5, Wafaa Zaaraoui1,4, and Jean-Philippe Ranjeva1,4

1Aix-Marseille University, CNRS, CRMBM UMR 7339, Medical School of Marseille, Marseille, France, Metropolitan, 2AP-HM, CHU Timone, Department of Imaging, CEMEREM, Marseille, France, 3Siemens Healthineers, Saint-Denis, France, Metropolitan, 4AP-HM, CHU Timone, Department of Imaging, CEMEREM, Marseille, France, Metropolitan, 5AP-HM, CHU Timone, Department of Neurology, Marseille, France, Metropolitan

To determine the metabolic counterparts of cerebral total sodium accumulations in patients with Multiple Sclerosis, we acquired fast 3D-1H-EPSI and Density-adapted 3D-UTE 23Na MRI at 3 Tesla covering the whole brain in 21 patients and 20 volunteers. Patients showed increased 23Na and decreased NAA, Glx and Cho levels. Stepwise analyses highlights association of 23Na accumulations with i) decreased NAA and Glx levels and increased Cho levels within GM, ii) with decreased NAA and increased Cho levels within NAWM and T2 lesion compartments. Clinical status of patients assessed by MSFC was correlated to GM and NAWM 23Na, NAA and Glx levels.

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