Abstract #0212

Metabolic counterparts of sodium accumulation in Multiple Sclerosis: A whole brain 1H-MRSI and 23Na-MRI study

Maxime Donadieu^1,2,3, Adil Maarouf^1,4, Yann Le Fur^1,4, Soraya Gherib^1,4, Elisabeth Soulier^1,4, Lauriane Pini^1,4, Stanislas Rapacchi^1,4, Sylviane Confort-Gouny^1,4, Maxime Guye^1,4, Jean Pelletier⁵, Bertrand Audoin⁵, Wafaa Zaaraoui^1,4, and Jean-Philippe Ranjeva^1,4

¹Aix-Marseille University, CNRS, CRMBM UMR 7339, Medical School of Marseille, Marseille, France, Metropolitan, ²AP-HM, CHU Timone, Department of Imaging, CEMEREM, Marseille, France, ³Siemens Healthineers, Saint-Denis, France, Metropolitan, ⁴AP-HM, CHU Timone, Department of Imaging, CEMEREM, Marseille, France, Metropolitan, ⁵AP-HM, CHU Timone, Department of Neurology, Marseille, France, Metropolitan

To determine the metabolic counterparts of cerebral total sodium accumulations in patients with Multiple Sclerosis, we acquired fast 3D-¹H-EPSI and Density-adapted 3D-UTE ²³Na MRI at 3 Tesla covering the whole brain in 21 patients and 20 volunteers. Patients showed increased ²³Na and decreased NAA, Glx and Cho levels. Stepwise analyses highlights association of ²³Na accumulations with i) decreased NAA and Glx levels and increased Cho levels within GM, ii) with decreased NAA and increased Cho levels within NAWM and T₂ lesion compartments. Clinical status of patients assessed by MSFC was correlated to GM and NAWM ²³Na, NAA and Glx levels.

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