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Abstract #0214

Combining QSM and MWF in multiple sclerosis: a marker for the inflammatory state of MS lesions?

Carsten Stueber1,2, Alexey Dimov1, Kofi Deh1, Thanh Nguyen1, Yi Wang1, and David Pitt2

1Weill Cornell Medicine, New York, NY, United States, 2Yale University, New Haven, CT, United States

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. In particular, excess iron is considered to play an essential role in lesion activity. In this study, we combine iron-reflecting quantitative susceptibility mapping (QSM) and myelin water fraction (MWF) with histology in post-mortem tissue. Our results show that elevated iron concentrations at the lesion rim reflect pro-inflammatory microglial activity, suggesting to use QSM to determine levels of lesion inflammation and MWF for detecting ongoing demyelination.

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