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Abstract #0226

Demonstrating the Clinical Feasibility of a Rapid Non-Contrast MRI Protocol for Detection and Quantification of Hepatic Steatosis and Iron Overload

B. Dustin Pooler1 and Scott B. Reeder1

1University of Wisconsin, Madison, WI, United States

Many clinical scenarios necessitate evaluation for hepatic steatosis or iron overload without indication for a complicated MR exam. Emerging confounder-corrected chemical shift encoded MRI (CSE-MRI) techniques can provide simultaneous estimation of liver proton density fat fraction (PDFF) and R2* as biomarkers of steatosis and iron overload, respectively. We have developed a highly focused CSE-MRI protocol which obtains these metrics in approximately 5 minutes of table time. Our initial clinical experience has shown this protocol to be feasible for evaluation of patients ranging from pediatric to geriatric, with clinically significant disease detected in a large fraction of patients scanned to date.

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