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Abstract #0240

Global signal regression alters the correlation between resting-state BOLD fluctuations and EEG vigilance measures

Maryam Falahpour1, Alican Nalci1, Chi Wah Wong1, and Thomas Liu1

1Center for functional MRI, University of California San Diego, San Diego, CA, United States

Global signal regression (GSR) is a commonly used preprocessing approach in the analysis of resting state fMRI data. Utilizing simultaneously acquired EEG/fMRI data in humans, we found that GSR alters the correlation between the resting-state BOLD fluctuations and EEG vigilance. We show that GSR reveals BOLD-EEG correlations that are otherwise obscured and use a time segmentation approach to argue that the observed effects are not simply an artifact of GSR.

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