Abstract #0242

Functional Neuroimaging in the Brain using Magnetic Resonance Elastography

Samuel Patz^1,2, Navid Nazari³, Paul E. Barbone⁴, Ben Fabry⁵, Dan Fovargue⁶, David Nordsletten⁶, and Ralph Sinkus⁶

¹Radiology, Brigham & Women's Hospital, Boston, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Biomedical Engineering, Boston University, Boston, MA, United States, ⁴Mechanical Engineering, Boston University, Boston, MA, United States, ⁵Physics, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Biomedical Engineering, Kings College London, London, United Kingdom

Using electrical stimulation of the hind limb, Magnetic Resonance Elastography (MRE) was used to observe localized changes in the complex shear modulus G=G’ + iG’’ of the mouse brain cortex. “Stimulation” and “no stimulation” paradigms were alternated every 10s to avoid habituation. An average increase of ~14% in G’ was observed whereas no significant change was seen for G’’. The effect was observed in six of seven mice studied. The mechanism responsible for this effect is hypothesized to be due to calcium influx into the neuronal cells.

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