Using electrical stimulation of the hind limb, Magnetic Resonance Elastography (MRE) was used to observe localized changes in the complex shear modulus G=G’ + iG’’ of the mouse brain cortex. “Stimulation” and “no stimulation” paradigms were alternated every 10s to avoid habituation. An average increase of ~14% in G’ was observed whereas no significant change was seen for G’’. The effect was observed in six of seven mice studied. The mechanism responsible for this effect is hypothesized to be due to calcium influx into the neuronal cells.