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Abstract #0242

Functional Neuroimaging in the Brain using Magnetic Resonance Elastography

Samuel Patz1,2, Navid Nazari3, Paul E. Barbone4, Ben Fabry5, Dan Fovargue6, David Nordsletten6, and Ralph Sinkus6

1Radiology, Brigham & Women's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Biomedical Engineering, Boston University, Boston, MA, United States, 4Mechanical Engineering, Boston University, Boston, MA, United States, 5Physics, University of Erlangen-Nuremberg, Erlangen, Germany, 6Biomedical Engineering, Kings College London, London, United Kingdom

Using electrical stimulation of the hind limb, Magnetic Resonance Elastography (MRE) was used to observe localized changes in the complex shear modulus G=G’ + iG’’ of the mouse brain cortex. “Stimulation” and “no stimulation” paradigms were alternated every 10s to avoid habituation. An average increase of ~14% in G’ was observed whereas no significant change was seen for G’’. The effect was observed in six of seven mice studied. The mechanism responsible for this effect is hypothesized to be due to calcium influx into the neuronal cells.

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