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Abstract #0254

Characteristic Changes of Volume and Shape of Subcortical Structures in Obsessive-Compulsive Disorder

Lianqing Zhang1, Xinyu Hu1, Ming Zhou1, Lu Lu1, Xiaoxiao Hu1, and Xiaoqi Huang1

1Radiology Department, Huaxi MR Research Center (HMRRC),West China Hospital of Sichuan University, Chengdu, People's Republic of China

We analysis subcortical nucleus volume and shape alterations in a relatively large sample of drug-naive adult patients with Obsessive-Compulsive disorder by using an automatically segmentation and vertex-based shape analysis protocol. Our findings indicated that (i)Gender effects were found in OCD, male patients seems are affected in reward system whereas females might have more disrupted stratum-pallidum-thalamus pathway which might be related to chronic stress. (ii)Shape analysis may provide more anatomical change information from a different perspective. Future structural research should consider shape and volume alterations together when explore brain changes.

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