Abstract #0267

Alterations in brain structural connectivity in comatose cardiac arrest patients

Ona Wu¹, Eric S. Rosenthal², Gaston Cudemus-Deseda³, Brian L. Edlow², Marjorie Villien¹, Brittany B. Mills², Joseph T. Giacino⁴, James L. Januzzi⁵, Ming Ming Ning², W. Taylor Kimberly², William A. Copen⁶, Pamela W. Schaefer⁶, and David M. Greer⁷

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, ³Department of Cardiac Anesthesiology and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States, ⁴Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, MA, United States, ⁵Department of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, MA, United States, ⁶Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁷Department of Neurology, Yale School of Medicine, New Haven, CT, United States

Cardiac arrest patients in coma after restoration of spontaneous circulation were prospectively studied to determine whether variability in structural connectivity can discriminate patients likely to recover consciousness from those who will not. Compared to healthy controls, cardiac arrest patients overall had significantly lower values in the following structural connectivity parameters: global efficiency, clustering coefficient, and degree. Cardiac arrest patients who failed to recover alertness had a significantly lower global clustering coefficient compared to patients who woke up. Alterations in structural connectivity may play an important role in predicting recovery and guiding patient management decisions in comatose cardiac arrest patients.

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