This study introduces a novel 2D-EPI-navigated prospective motion correction technique to correct for in-plane and through-plane motion that establishes a flexible steady-state during the measurement. It utilizes a rigid-body multi-slice-to-volume registration using three parallel and well-separated EPI slices. The technique was evaluated using a well-defined motion protocol with translations up to 13mm and rotations up to 9°, which was executed by a volunteer. Results show a substantial reduction of motion parameters to below ±0.5mm/±0.5° and an increase in overall image quality in comparison to a no-motion scan. The navigator acquisition scheme can be adapted for use with a range of multi-shot 2D sequences to allow EPI navigators to be acquired with limited effect on the overall scan time or the contrast-to-noise ratio.
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