Abstract #0304

On the impact of real-time motion and B0 correction during 3D-MRSI measurements in Parkinson’s, Mild Cognitive Impairment and young/elderly controls

Eva Heckova¹, Michal Považan^1,2, Bernhard Strasser¹, Petra Hnilicova³, Ovidiu C Andronesi⁴, Andre van der Kouwe⁴, Jozef Ukropec⁵, Siegfried Trattnig^1,2, and Wolfgang Bogner^1,2

¹High Field MR Centre, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ³Biomedical Center Martin, Division of Neurosciences, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ⁴Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ⁵Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia

Presence of motion during MRSI acquisition and scanner instabilities affect the localization accuracy of the measurement and consequential quality of the data. We determined the extent of inter-acquisition head movement, frequency and B0 shim changes during approximately 20 min MEGA-edited MRSI scan with integrated vNav in 4 different groups of subject, with significantly larger amount of head motion in Parkinsons's patients, Mild Cognitive Impairment and elderly controls comparing to young healthy volunteers. With real-time motion, B0 correction and reacquisition we obtained satisfactory data quality in all groups of subjects, which makes it a valuable tool for spectral quality accurance.

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