Abstract #0330

13C NMR metabolic flux analysis of mantle cell lymphoma cells to Bruton tyrosine kinase inhibitors

Seung-Cheol Lee¹, Alex Shestov¹, Stephen Pickup¹, Jeff Roman¹, Mariusz Wasik², and Jerry Glickson¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States

We analyzed various metabolic fluxes of mantle cell lymphoma cells upon Bruton tyrosine kinase signaling inhibitors using 13C NMR and a bonded cumomer modeling method and identified 1H NMR biomarkers translatable to clinic.

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