13C NMR metabolic flux analysis of mantle cell lymphoma cells to Bruton tyrosine kinase inhibitors
Seung-Cheol Lee1, Alex Shestov1, Stephen Pickup1, Jeff Roman1, Mariusz Wasik2, and Jerry Glickson1
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States
We analyzed various metabolic fluxes of mantle cell lymphoma cells upon Bruton tyrosine kinase signaling inhibitors using 13C NMR and a bonded cumomer modeling method and identified 1H NMR biomarkers translatable to clinic.
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