Meeting Banner
Abstract #0337

Noninvasive Functional Evaluation of Coronary Stenosis Using MR Instantaneous wave-Free Ratio (MR-iFR): Pilot patient study using invasive fractional flow reserve as a reference

Zixin Deng1,2, Sang-Eun Lee3, Zhaoyang Fan1, Christopher Nguyen1, Yibin Xie1, Jianing Pang1, Xiaoming Bi4, Qi Yang1, Byoung-Wook Choi5, Jung-Sun Kim3, Daniel Berman1, Hyuk-Jae Chang3, and Debiao Li1

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Cardiology, Severance Cardiovascular Hospital, 4Siemens Healthcare R&D, 5Radiology, Severance Cardiovascular Hospital

In patients with suspected coronary artery disease undergoing invasive coronary angiography, approximately half has nonsignificant stenosis (stenotic lesions that may not induce ischemia), leading to frequent and unnecessary invasive procedures. Previously, we proposed a noninvasive technique for functional evaluation of coronary stenosis using PC-MRI and navier-stokes equations. In this study, we evaluated the feasibility of the technique in patients, using invasive fractional flow reserve as a reference. Good correlation was observed between noninvasive and invasive techniques with high specificity and negative-predictive-value, demonstrating the potential of the proposed technique in identifying patients with functionally nonsignificant stenosis and eliminating unnecessary invasive procedures.

This abstract and the presentation materials are available to members only; a login is required.

Join Here