In patients with suspected coronary artery disease undergoing invasive coronary angiography, approximately half has nonsignificant stenosis (stenotic lesions that may not induce ischemia), leading to frequent and unnecessary invasive procedures. Previously, we proposed a noninvasive technique for functional evaluation of coronary stenosis using PC-MRI and navier-stokes equations. In this study, we evaluated the feasibility of the technique in patients, using invasive fractional flow reserve as a reference. Good correlation was observed between noninvasive and invasive techniques with high specificity and negative-predictive-value, demonstrating the potential of the proposed technique in identifying patients with functionally nonsignificant stenosis and eliminating unnecessary invasive procedures.
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