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Abstract #0359

Simultaneous acquisition of oxygen extraction fraction and cerebral blood flow during brain activation

Yayan Yin1, Yaoyu Zhang1, Yang Fan2, Bing Wu2, and Jia-Hong Gao1

1Center for MRI Research, Peking University, Beijing, People's Republic of China, 2MR Research China, GE Healthcare, Beijing, People's Republic of China

The development of neuroimaging methods to obtain oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) is crucial for understanding mechanisms underlying physiological function and neuronal activity. In the present study, a novel technique termed FAIR-MGESSE combined flow sensitive alternating inversion recovery (FAIR) and multiecho gradient echo sampling of the spin echo (MGESSE) techniques. It is proposed for acquiring OEF and ASL maps in a single repetition time to determine the relative change in CMRO2 in human subjects. Relative changes in CBF, OEF and CMRO2 were measured during the visual task and the results agree well with expectations.

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