Abstract #0359

Simultaneous acquisition of oxygen extraction fraction and cerebral blood flow during brain activation

Yayan Yin¹, Yaoyu Zhang¹, Yang Fan², Bing Wu², and Jia-Hong Gao¹

¹Center for MRI Research, Peking University, Beijing, People's Republic of China, ²MR Research China, GE Healthcare, Beijing, People's Republic of China

The development of neuroimaging methods to obtain oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO₂) is crucial for understanding mechanisms underlying physiological function and neuronal activity. In the present study, a novel technique termed FAIR-MGESSE combined flow sensitive alternating inversion recovery (FAIR) and multiecho gradient echo sampling of the spin echo (MGESSE) techniques. It is proposed for acquiring OEF and ASL maps in a single repetition time to determine the relative change in CMRO₂ in human subjects. Relative changes in CBF, OEF and CMRO₂ were measured during the visual task and the results agree well with expectations.

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