Meeting Banner
Abstract #0370

Assessment of Nonalcoholic Fatty Liver Disease (NAFLD) Activity Score (NAS) with MR Elastography (MRE)

Meng Yin1, Alina M. Allen2, Kevin J. Glaser1, Sudhakar K. Venkatesh1, Taofic Mounajjed3, Vijay Shah2, and Richard L. Ehman1

1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States, 3Anatomic Pathology, Mayo Clinic, Rochester, MN, United States

To investigate the utility of a hepatic imaging protocol “hepatogram”, which includes multi-parametric MR Elastography (MRE) and fat fraction assessment, in predicting nonalcoholic fatty liver disease (NAFLD) activity score (NAS: 0-8). In both preclinical and clinical subjects with histology-proven NAFLD, generalized linear models of liver stiffness, damping ratio and fat fraction successfully distinguished each NAS score with excellent accuracy (AUROC>0.89 for all). Misclassifications in distinguishing steatohepatitis (NAS≥3) from NAFLD (NAS<3) was only 2/64 mice and 3/51 human subjects. Our findings indicate the hepatogram imaging protocol can predict NAS score and may be useful to monitor NAFLD disease progression and regression.

This abstract and the presentation materials are available to members only; a login is required.

Join Here