To investigate the utility of a hepatic imaging protocol “hepatogram”, which includes multi-parametric MR Elastography (MRE) and fat fraction assessment, in predicting nonalcoholic fatty liver disease (NAFLD) activity score (NAS: 0-8). In both preclinical and clinical subjects with histology-proven NAFLD, generalized linear models of liver stiffness, damping ratio and fat fraction successfully distinguished each NAS score with excellent accuracy (AUROC>0.89 for all). Misclassifications in distinguishing steatohepatitis (NAS≥3) from NAFLD (NAS<3) was only 2/64 mice and 3/51 human subjects. Our findings indicate the hepatogram imaging protocol can predict NAS score and may be useful to monitor NAFLD disease progression and regression.
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