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Abstract #0388

Whole-brain multi-slice multi-spoke parallel transmit RF pulse design in the large flip angle regime at 7 Tesla

Vincent Gras1, Alexandre Vignaud1, Alexis Amadon1, Franck Mauconduit2, Denis Le Bihan1, and Nicolas Boulant1

1UNIRS, CEA/DRF/I2BM/Neurospin, Gif-sur-Yvette, France, 2Siemens Healthcare, Saint Denis, France

At ultra-high field, transmit RF field inhomogeneity mitigation methods exploiting parallel transmission and multi-spoke pulses are readily applicable for brain imaging with small flip angle (FA) protocols. The extension to large FAs yet appears more challenging due to the inherent computationally extensive calculations. Dealing now with multi-slice applications, where specific absorption rate (SAR) issues often come into play, a SAR-aware slice-specific pulse design algorithm can improve significantly the output. This work thus presents a large FA slice-specific multi-spoke pulse design approach enforcing explicitely SAR constraints and, to reduce computations, where the spin dynamics is approximated with Average Hamiltonian Theory.

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