At ultra-high field, transmit RF field inhomogeneity mitigation methods exploiting parallel transmission and multi-spoke pulses are readily applicable for brain imaging with small flip angle (FA) protocols. The extension to large FAs yet appears more challenging due to the inherent computationally extensive calculations. Dealing now with multi-slice applications, where specific absorption rate (SAR) issues often come into play, a SAR-aware slice-specific pulse design algorithm can improve significantly the output. This work thus presents a large FA slice-specific multi-spoke pulse design approach enforcing explicitely SAR constraints and, to reduce computations, where the spin dynamics is approximated with Average Hamiltonian Theory.
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