Abstract #0392

Age-related neuropathologies associated with white matter hyperintensities burden: a study of a community cohort of older adults.

Nabil Alqam¹, Arnold Evia¹, Luis Filipe Campos Cardoso¹, Lucas Fagundes Lopes¹, Diego Vieira Pereira¹, Julie A. Schneider^2,3,4, Sue E. Leurgans^2,3, David A. Bennett^2,3, and Konstantinos Arfanakis^1,2,5

¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States, ³Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States, ⁴Department of Pathology, Rush University Medical Center, Chicago, IL, United States, ⁵Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, United States

White matter hyperintensities (WMH) are lesions commonly observed in the brain of older adults, and have been associated with lower cognitive function, lower motor performance, and increased risk of dementia. The purpose of this work was to investigate the neuropathologic correlates of WMH burden by combining ex-vivo MRI and pathology on a large community cohort of older adults.

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