Abstract #0414

Boundary shift integral to compute brain and cervical spinal cord longitudinal volume changes using the same 3DT1w volumetric scans in multiple sclerosis

Ferran Prados^1,2, Özgür Yaldizli³, Manuel Jorge Cardoso¹, Marios C Yiannakas², Francesco Grussu², Esther Ruberte⁴, Jens Wuerfel⁴, Frederik Barkhof^1,2,5, Claudia AM Gandini Wheeler-Kignshott^2,6,7, and Sebastien Ourselin¹

¹Translational Imaging Group, CMIC, Dep. of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²UCL Institute of Neurology, Queen Square MS Centre, University College London, London, United Kingdom, ³Department of Neurology, University Hospital Basel, Switzerland, ⁴Medical Image Analysis Center Basel, Switzerland, ⁵Radiology & Nuclear Medicine, VU University Medical Centre, Netherlands, ⁶Department of Brain and Behavioural Sciences, University of Pavia, Italy, ⁷Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Italy

Brain atrophy is considered to be the net accumulative irreversible disease burden as the ultimate consequence of different pathological processes found in the multiple sclerosis brain. A recent cross-sectional study demonstrated the possibility to assess atrophy of the spinal cord using 3DT1w brain volumetric scans. However, to date, no unified technique has been presented to longitudinally assess brain and spinal cord atrophy using the same MRI acquisition. Here we present a proof-of-concept data from a pipeline that uses the boundary shift integral to compute both brain and cervical spinal cord atrophy rates using the same 3DT1w brain volumetric scans.

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