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Abstract #0414

Boundary shift integral to compute brain and cervical spinal cord longitudinal volume changes using the same 3DT1w volumetric scans in multiple sclerosis

Ferran Prados1,2, Özgür Yaldizli3, Manuel Jorge Cardoso1, Marios C Yiannakas2, Francesco Grussu2, Esther Ruberte4, Jens Wuerfel4, Frederik Barkhof1,2,5, Claudia AM Gandini Wheeler-Kignshott2,6,7, and Sebastien Ourselin1

1Translational Imaging Group, CMIC, Dep. of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2UCL Institute of Neurology, Queen Square MS Centre, University College London, London, United Kingdom, 3Department of Neurology, University Hospital Basel, Switzerland, 4Medical Image Analysis Center Basel, Switzerland, 5Radiology & Nuclear Medicine, VU University Medical Centre, Netherlands, 6Department of Brain and Behavioural Sciences, University of Pavia, Italy, 7Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Italy

Brain atrophy is considered to be the net accumulative irreversible disease burden as the ultimate consequence of different pathological processes found in the multiple sclerosis brain. A recent cross-sectional study demonstrated the possibility to assess atrophy of the spinal cord using 3DT1w brain volumetric scans. However, to date, no unified technique has been presented to longitudinally assess brain and spinal cord atrophy using the same MRI acquisition. Here we present a proof-of-concept data from a pipeline that uses the boundary shift integral to compute both brain and cervical spinal cord atrophy rates using the same 3DT1w brain volumetric scans.

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