Abstract #0417

On the Relationship between Tissue Damage in Cervical Spinal Cord and Brain in Multiple Sclerosis.

Biao Xiang¹, Jie Wen², Amber Salter³, Anne H. Cross³, and Dmitriy A. Yablonskiy²

¹Department of Chemistry, Washington University in St. Louis, Saint Louis, MO, United States, ²Department of Radiology, Washington University in St. Louis, St. Louis, MO, United States, ³Department of Neurology, Washington University in St. Louis, St. Louis, MO, United States

We examined quantitative relationships between tissue damage in the cervical spinal cord (characterized by cross-sectional area (CSA)) and cortical gray matter (GM) (characterized by thickness and tissue specific R2^* values) in multiple sclerosis (MS) patients, and determined relative contributions of these to neurologic disability. We found correlations between CSA and GM R2^* values and thickness of several cortical regions. Compared with cortical R2^* and thickness, cervical spinal cord CSA correlated better with neurological impairment status. CSA, thickness and age-corrected R2^* values all differentiated MS subjects from healthy Controls. CSA and GM thickness could further distinguish MS clinical subtypes.

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