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Abstract #0417

On the Relationship between Tissue Damage in Cervical Spinal Cord and Brain in Multiple Sclerosis.

Biao Xiang1, Jie Wen2, Amber Salter3, Anne H. Cross3, and Dmitriy A. Yablonskiy2

1Department of Chemistry, Washington University in St. Louis, Saint Louis, MO, United States, 2Department of Radiology, Washington University in St. Louis, St. Louis, MO, United States, 3Department of Neurology, Washington University in St. Louis, St. Louis, MO, United States

We examined quantitative relationships between tissue damage in the cervical spinal cord (characterized by cross-sectional area (CSA)) and cortical gray matter (GM) (characterized by thickness and tissue specific R2* values) in multiple sclerosis (MS) patients, and determined relative contributions of these to neurologic disability. We found correlations between CSA and GM R2* values and thickness of several cortical regions. Compared with cortical R2* and thickness, cervical spinal cord CSA correlated better with neurological impairment status. CSA, thickness and age-corrected R2* values all differentiated MS subjects from healthy Controls. CSA and GM thickness could further distinguish MS clinical subtypes.

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