This study aims to validate a free-breathing DCE-MRI in HCC patients using gadoxetic acid, and to determine the relationship between DCE-MRI parameters and histological results. Perfusion parameters (Ktrans, Kep, Ve and iAUC) from 34 patients were compared with CT results and correlated with Ki67 indices and the histological grades of HCC. Significant relationship was found between DCE-MRI and CT results, indicating the validity of this protocol in evaluating the vascular change of HCC. The DCE-MRI derived Ktrans and iAUC were significantly correlated with the histological grades of HCC, suggesting the potential of those parameters in predicting the malignancy of tumors.
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