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Abstract #0442

Wave-CAIPI for Highly Accelerated MP-RAGE Imaging

Daniel Polak1,2, Kawin Setsompop1,3,4, Stephen F. Cauley1,3, Borjan A. Gagoski3,5, Himanshu Batt6, Florian Maier2, Lawrence L. Wald1,3,4, and Berkin Bilgic1,3

1Massachusetts General Hospital, Boston, MA, United States, 2German Cancer Resarch Center, Heidelberg, Germany, 3Harvard Medical School, Boston, MA, United States, 4Harvard-MIT Health Sciences and Technology, Boston, MA, United States, 5Boston Children’s Hospital, Boston, MA, United States, 6Siemens Medical Solutions Inc, Malvern, PA, United States

We introduce a highly accelerated T1-weighted MP-RAGE acquisition that utilizes a novel reordering scheme and Wave-CAIPI encoding to retain high image quality. R=9-fold accelerated in vivo MP-RAGE scans were performed in 71 sec, with maximum and average g-factor of gmax=1.27 and gavg=1.06. Compared to the state-of-the-art 2D-CAIPIRINHA method, this is a factor of 4.6/1.4 improvement in gmax/gavg. In addition, we demonstrate a 57 sec acquisition at 7T with R=12-fold acceleration. This acquisition had a g-factor performance of gmax=1.15 and gavg=1.04. Wave encoding overcomes the g-factor noise amplification penalty and allows for an order of magnitude acceleration of MP-RAGE acquisitions.

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