Volumetric fast spin-echo (3DFSE) imaging is clinically desirable because of its robustness to off-resonance and its utility for obtaining many types of image contrasts at isotropic resolution. However, its routine clinical use is inhibited by blurring due to long echo trains needed to maintain scan efficiency. Her we present T1-T2 Shuffling, a 3DFSE-based acquisition and reconstruction scheme that mitigates image blur and retrospectively synthesize T1-weighted and T2-weighted image contrasts. The acquisition, an extension of T2 Shuffling, employs a randomizing echo train view ordering with variable repetition times (TRs). The use of short TRs increases scan efficiency while providing T1 sensitivity.
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