Functional Magnetic Resonance Spectroscopy (fMRS) could potentially provide much information on neurotransmitters, and hence, could shed light into excitation / inhibition imbalances. However, it was scarcely used, in particular in rodents, presumably due to low SNR. Here, we used a cryoprobe at 9.4T to record fMRS spectra in the rat in just a few minutes. SNR>50 was documented for the N-acetylaspartate resonance. We show statistically significant increases in Glutamate and decrease in GABA upon forepaw stimulation. Our results are suggestive of differential relaxation between vesicular and synaptic neurotransmitter pools, and are promising for more detailed investigations, e.g., using optogenetics.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords