Abstract #0460

Simultaneous multi-slice whole-brain VASO-BOLD, ToF, and SWI at 3T to investigate the vascular contributions in resting-state networks

Michaël Bernier¹, Guillaume Gilbert², Stephen C Cunnane^3,4,5, and Kevin Whittingstall⁶

¹Nuclear medecine and radiobiology, Université de Sherbrooke, Sherbrooke, QC, Canada, ²MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, ³Research center of aging, CSSS-IUGS, Sherbrooke, QC, Canada, ⁴Department of Pharmacology and Physiology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Department of Medecine, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Diagnostic radiology, Université de Sherbrooke, Sherbrooke, QC, Canada

The structural nature of BOLD and CBV fluctuations during resting-state remains unclear. To address this, we first developed a simultaneous multi-slice VASO-BOLD EPI sequence at 3T and isolated resting-state VASO- and BOLD- based networks. We then performed ToF and SWI to quantify the arterial and venous contributions in each network. Overall, both BOLD and VASO showed similar networks which were spatially localized near large veins. Also, similar proportions of vasculature were observed throughout all networks. These results suggest that simultaneous BOLD-CBV acquisitions are feasible at 3T and that their resting state networks are spatially and structurally similar.

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