Abstract #0465

Deactivation responses induced by acupuncture are associated with changes in GABA concentrations: a BOLD fMRI and MEGA-PRESS 1H-MRS Study

Jiliang Fang¹, Yuanyuan Chen¹, Yanping Zhao¹, Guiyong Liu¹, Xiaoling Wang¹, Feng Feng², Bo Hou², Bingzhen Lei³, Xiaojiao Li¹, Ahn Sinyeob⁴, and Tianyi Qian⁵

¹Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China, ²Peking Union Hospital, Peking Union Medical University, Beijing, People's Republic of China, ³Beijing Institute of Technology, Beijing, People's Republic of China, ⁴Siemens Healthcare, MR Collaboration, CA, United States, ⁵Siemens Healthcare, MR Collaboration NE Asia, Beijing, People's Republic of China

This study investigated the neurological mechanism that mediates the deactivation of the medial prefrontal cortex induced by acupuncture. Gamma-aminobutyric acid (GABA) concentrations before and immediately after acupuncture stimulation in healthy volunteers were assessed with MEGA-PRESS 1H-MRS. We found that GABA concentrations in the medial prefrontal cortex decreased significantly after acupuncture stimulation compared with control stimulation with Von Frey sensory. Analysis of the task-functional magnetic resonance image (fMRI) acquired during acupuncture showed deactivation in the same area. These results demonstrated that the decreased blood oxygenation level dependent (BOLD) response induced by acupuncture was associated with inhibitory effects.

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