Abstract #0544

Non-contrast assessment of vasodilator response using native myocardial T1 and T2 mapping and Arterial Spin Labeled CMR

Nilesh R Ghugre^1,2,3, Hung P Do⁴, Kenneth Chu³, Venkat Ramanan¹, Krishna S Nayak⁵, and Graham A Wright^1,2,3

¹Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ²Schulich Heart Program, Sunnybrook Research Institute, Toronto, ON, Canada, ³Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁴Department of Physics and Astronomy, University of Southern California, Los Angeles, CA, United States, ⁵Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States

Myocardial vasodilator response is an important indicator of microvascular function and integrity in ischemic injury. The objective of our study was to systematically compare myocardial stress response with native contrast mechanisms involving quantitative T2, T1 and Arterial spin labeled (ASL) imaging. Our findings suggest that oxygenation (T2 BOLD effect), blood volume (T1 effect) and perfusion (ASL) taken together could offer a complementary contrast-free framework to identify vasodilator dysfunction in heart disease. These could potentially offer insights into the myocardial remodeling process particularly in the remote territory, which develops hypertrophy and fibrosis in the high-risk patients in the chronic stage.

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