The myocardium consists of a complex 3-dimensional (3D) microstructure has been shown to be perturbed in the presence of myocardial ischemia. Recently, diffusion tensor magnetic resonance imaging (DT-CMR) was introduced which can characterize the 3D tissue microstructure in intact myocardium. However, past histologic validation of DTI has been limited since traditional pathology allows only 2D optical microscopy after potentially destructive tissue sectioning. We present a novel approach to validate the derivation of the myocardial fiber orientation (MFO) using DT-CMR with 3D histology using a non-destructive, transparent-tissue preparation technique (CLARITY). Results indicate MFO derived from 3D histology and DT-CMR are strongly concordant.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords