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Abstract #0568

CMRO2 Quantification in Human Brain with Direct 17O-MRI: Profile Likelihood Analysis for Optimization of Temporal Resolution

Dmitry Kurzhunov1, Robert Borowiak1,2,3, Ali Caglar Özen1, and Michael Bock1

1Dept. of Radiology, Medical Physics, Medical Center – University of Freiburg, Freiburg, Germany, 2German Cancer Consortium (DKTK), Heidelberg, Germany, 3German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study the temporal resolution of 17O-MRI protocols for quantification of the cerebral metabolic rate of oxygen consumption (CMRO2) in human brain were optimized using the profile likelihood (PL) method. For this, retrospective analysis of the influence of temporal resolution on the CMRO2 values and their PL-based confidence intervals (CI) was performed. Dynamic 17O-MRI was implemented with a 3D golden-angle radial acquisition during and after inhalation of 17O gas. The results showed that 17O-MRI data acquired at a temporal resolution 120≤Δt≤165 seconds gave identifiable CMRO2 values of 0.82‑1.18/0.92‑1.42 µmol/gtissue/min in WM/GM brain regions.

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