Abstract #0579

Variable Projection SENSE for Reference-free EPI Nyquist Ghost Correction

Yue Zhang^1,2,3, Mengye Lyu^1,2, Yilong Liu^1,2, Yifan Chen³, and Ed X. Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, People's Republic of China, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, People's Republic of China, ³Department of Electrical and Electronic Engineering, Southern University of Science and Technology, Shenzhen, People's Republic of China

In this abstract, variable projection sensitivity encoding (VP-SENSE) method is proposed to correct phase error, which is the main cause of Nyquist ghost in EPI. In VP-SENSE, the unknown images are fully represented by a function of phase error and the least squares solution is sought regarding phase error only. Our results have indicated that this approach can robustly remove ghost without apparent SNR penalty. With prior phase error information as constraints, ghost level can be further reduced and the SNR loss can be further minimized through constrained variable projection approach (CVP-SENSE).

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