We compare the effects of motion and nuisance regression on highly accelerated resting-state fMRI of 10 subjects scanned at 3T using state-of-the-art simultaneous multi-slice EPI and segmented 3D-EPI with controlled aliasing. While both TR-matched protocols are per design fast enough to separate the cardiac frequency peak from BOLD signal, gray matter signal-to-noise ratio with the 3D-EPI protocol improves almost twice as much as compared to the SMS-EPI protocol. Template based rotation functional connectivity analysis on average shows greater statistical loadings for several known networks when using cleaned 3D-EPI data than when using cleaned SMS-EPI data.
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