The proposed DTI study aims at quantification of the effect of experimentally induced dorsal column lesion at upper cervical level (C4/5) in squirrel monkeys. Diffusion parametric changes based on the directionality, and mobility of water molecules in the cellular environment, characterizes the spinal cord. Change in diffusion parameters on specific white matter tracks above and below the SCI location were compared between the lesioned and normal side of the spinal cord. A systematic group analysis of the inter-ROI changes along the white matter pathways can therefore be used to correlate the loss and recovery of sensory/motor functions over time.
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