The overall goal of this work is to apply pharmacological arterial spin labeling (ASL) to investigate fundamental hypotheses regarding the role of dopamine agonist (DAgonist) therapy in patients with Parkinson’s disease and impulse control behavior (ICB). Parkinson’s disease patients (n=35; age range=40-79 years; gender=23/12 males/females) receiving DAgonist therapy, with (n=17) and without (n=18) DAgonist-induced ICB were scanned at 3T using cerebral blood flow (CBF)-weighted pCASL MRI. Region-of-interest analyses revealed significantly increased bilateral ventral striatal (P<0.01) CBF in patients with ICB in the On- DAgonist state; voxel-wise analysis of CBF confirmed widespread DAgonist-induced CBF increases in mesolimbic, mesocortical, and midbrain regions.
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