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Abstract #0612

Pharmacological arterial spin labeling reveals distinct mesocorticolimbic blood flow in Parkinson’s disease patients with compulsive reward-driven behaviors

Daniel Claassen1, Adam Stark2, Charis Spears2, Kalen Petersen3, Scott Wylie2, Nelleke van Wouwe2, Robert Kessler4, David Zald5, and Manus J Donahue3

1Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Neurology, Vanderbilt University Medical Center, 3Radiology, Vanderbilt University Medical Center, 4Radiology, University of Alabama at Birmingham, 5Psychology, Vanderbilt University Medical Center

The overall goal of this work is to apply pharmacological arterial spin labeling (ASL) to investigate fundamental hypotheses regarding the role of dopamine agonist (DAgonist) therapy in patients with Parkinson’s disease and impulse control behavior (ICB). Parkinson’s disease patients (n=35; age range=40-79 years; gender=23/12 males/females) receiving DAgonist therapy, with (n=17) and without (n=18) DAgonist-induced ICB were scanned at 3T using cerebral blood flow (CBF)-weighted pCASL MRI. Region-of-interest analyses revealed significantly increased bilateral ventral striatal (P<0.01) CBF in patients with ICB in the On- DAgonist state; voxel-wise analysis of CBF confirmed widespread DAgonist-induced CBF increases in mesolimbic, mesocortical, and midbrain regions.

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