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Abstract #0654

1-year Follow-Up of T1ρ for Assessing Radiocarpal Cartilage Matrix Changes after Anti-TNF treatment for Rheumatoid Arthritis: Preliminary Results

Eric Ku1, Valentina Pedoia1, Matthew Tanaka1, Hyo Jin Choi1, Ursula Heilmeier1, Andrew Burghardt1, Jonathan Graf2, John Imboden2, Thomas Link1, and Xiaojuan Li1

1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Department of Medicine, UCSF, San Francisco, CA, United States

MR T is used to investigate biochemical changes in cartilage composition, but few studies have looked at its application in radiocarpal wrist cartilage. In this study, we assess 1-year changes in T following rheumatoid arthritis treatment and its relationship with changes in clinical disease activity scores and patient-reported outcomes. Changes between 1-year and baseline T values correlated significantly with disease activity score changes and approached significance with patient-reported outcome changes during the same period. Changes in T values at 3-months also correlated significantly with 1-year changes in metacarpophalangeal and wrist bone erosion volume measured with high-resolution peripheral quantitative CT (HR-pQCT).

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