Abstract #0654

1-year Follow-Up of T1ρ for Assessing Radiocarpal Cartilage Matrix Changes after Anti-TNF treatment for Rheumatoid Arthritis: Preliminary Results

Eric Ku¹, Valentina Pedoia¹, Matthew Tanaka¹, Hyo Jin Choi¹, Ursula Heilmeier¹, Andrew Burghardt¹, Jonathan Graf², John Imboden², Thomas Link¹, and Xiaojuan Li¹

¹Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ²Department of Medicine, UCSF, San Francisco, CA, United States

MR T_1ρ is used to investigate biochemical changes in cartilage composition, but few studies have looked at its application in radiocarpal wrist cartilage. In this study, we assess 1-year changes in T_1ρ following rheumatoid arthritis treatment and its relationship with changes in clinical disease activity scores and patient-reported outcomes. Changes between 1-year and baseline T_1ρ values correlated significantly with disease activity score changes and approached significance with patient-reported outcome changes during the same period. Changes in T_1ρ values at 3-months also correlated significantly with 1-year changes in metacarpophalangeal and wrist bone erosion volume measured with high-resolution peripheral quantitative CT (HR-pQCT).

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