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Abstract #0673

Estimating breast tumor blood flow and blood volume using MRI: DCE vs IVIM

Leonidas Georgiou1, Nisha Sharma2, Daniel Wilson3, and David L Buckley1

1Division of Biomedical Imaging, University of Leeds, Leeds, United Kingdom, 2Department of Radiology, Leeds Teaching Hospital NHS Trust, 3Department of Medical Physics and Engineering, Leeds Teaching Hospital NHS Trust

There is an increasing interest on whether IVIM parameters can be used as surrogates of perfusion and thus complement information on tumor microstructure. DCE-MRI techniques on the other hand have been widely used to characterise perfusion and hence offer the opportunity to test this hypothesis. In this study, we use high temporal resolution DCE-MRI and IVIM-DWI techniques to monitor patients with advanced breast cancer at various stages of their neoadjuvant chemotherapy, and assess the physiological relationship between perfusion and IVIM parameters.

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