Abstract #0696

Laminar microstructure and subfield connectivity of the human hippocampus revealed with ultra-high field diffusion MRI at 11.7T

Manisha Aggarwal¹, Priya Sathyanarayan², and David W. Nauen³

¹Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ³Department of Pathology, Johns Hopkins University, Baltimore, MD, United States

In this work, we demonstrate high-field (11.7T) 3D diffusion MRI (dMRI) of the fixed human hippocampal formation to investigate its internal organization. The results of this study show delineation of fine hippocampal microstructure and inner connectivity of the human hippocampal subfields based on HARDI. Further, we demonstrate 3D reconstruction of intra-hippocampal subfield connectivity, e.g. the trisynaptic hippocampal circuit, using fODF-based probabilistic tractography with combined high spatial and angular resolution, which has important future applications for mapping of pathology-induced changes in the hippocampus in Alzheimer’s disease and related neurological disorders.

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